Publications

Jiao GS, Cregar L, Wang J, Millis SZ, Tang C, O'Malley S, Johnson AT, Sareth S, Larson J, Thomas G.
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.
Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19707-12.
PMID: 17179036 Pubmed Link PNAS link

Jiao GS, Kim S, Moayeri M, Cregar-Hernandez L, McKasson L, Margosiak SA, Leppla SH, Johnson AT.
Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy.
Bioorg Med Chem Lett. 2010 Nov 15;20(22):6850-3. PubMed PMID: 20864339; PubMed Central PMCID: PMC2965585. Pubmed Link

Kim S, Jiao GS, Moayeri M, Crown D, Cregar-Hernandez L, McKasson L, Margosiak SA, Leppla SH, Johnson AT.
Antidotes to anthrax lethal factor intoxication. Part 2: Structural modifications leading to improved in vivo efficacy.
Bioorg Med Chem Lett. 2011 Apr 1;21(7):2030-3. Epub 2011 Feb 18. PubMed PMID: 21334206; PubMed Central PMCID: PMC3059087. Pubmed Link

Thompson AA, Jiao GS, Kim S, Thai A, Cregar-Hernandez L, Margosiak SA, Johnson AT, Han GW, O'Malley S, Stevens RC.
Structural Characterization of Three Novel Hydroxamate-based Zinc Chelating Inhibitors of the C. botulinum Serotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility.
Biochemistry. 2011 Mar 24. [Epub ahead of print] PubMed PMID: 21434688. Pubmed Link

Cregar-Hernandez L, Jiao GS, Johnson AT, Lehrer AT, Wong TAS, Margosiak, S.
Small Molecule Pan-dengue and West Nile Virus NS3 Protease Inhibitors.
Antiviral Chem Chemother. 2011 in press.